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In the kidney, adenosine causes the afferent glomerular arteriola constriction and its releasing position, by an increase of sodium exposure the distal tubule, are triggered like after furosemide administration. Therefore, adenosine may be a mediator of occurred deterioration of kidney function in people who with acute heart failure to be. In addition, his acts to increase the sodium chloride in the proximal tubules recovery. New equipment be reason currently being investigated with the aim of maintaining of renal function during treatment for acute congestive heart failure and improve diuretic and natriuretic effects furosemide administering of patients with acute heart failure as. To this day rolofylline said first adenosine type 1A receptor antagonists be in a large study enrollment more than 2000 patients acute coronary insufficiency acute heart failure, who placebo-controlled randomized study of selective A1 adenosine receptor antagonist is rolofylline of patients suffering from acute RF volumes hospitals and hospital to judge effect of treatment on overload traffic jams and renal impairment Trial . The of this the ESC meeting in to the hotline Session III.
The reasons for of frequent coexistence of of renal and cardial dysfunction are varied. First, these two conditions are shared causes of like high blood pressure, diabetes, atherosclerosis, and joint pathogenetic mechanisms, such as neurohormonal and. Inflammatory activate and endothelial dysfunction In addition failure kidney dysfunction caused by the its hemodynamic abnormalities, namely low cardiac output and higher central vein pressure. Finally, the treatment of cardiac insufficiency also promote disturbed renal.