Medicine & Science in Sports & Exercise, the official journal of the American College of Sports Medicine and is of Lippincott Williams & Wilkins at 1-800-638-6423 read full text .to be difficult. For the in vivo delivery of siRNA has the potential to be used in gene therapy has how small RNAs enter mammalian cells all started with flowers: in the nineties of the last century discovered Norwegian explorer that additional copies a particular gene petunias in locked step up its activity previously thought. Previously thought. Several years later, it was found that the mechanism on the degradation of messenger RNA in the cells is based. In in the late nineties, the Nobel laureate Andrew Fire and Craig Mello, the technique of RNA interference, in which double-stranded RNA switches genes off efficiently and specifically. The scientists used the nematode Caenorhabditis elegans, to investigate. Then there were significant problems in trying the strategy used by Mello and Fire to transmit vertebrates. In particular, the administration of small RNAs, such as siRNAs announced in animals proved to be difficult. Although it was possible fatty acids. Successfully by using various methods such as high-pressure injections or in conjunction with cholesterol remained the underlying mechanism is unclear. Markus Stoffel, ETH professor at the Institute for Molecular Systems Biology, together with chemists from the Alnylam Company, has now succeeded in elucidating the mechanism for the uptake of siRNA in combination with fatty acids in mammals. The corresponding paper that was the journal the journal Nature Biotechnology and is also adorn the title page of the printed version in October, represents the basis for possible siRNA therapies, among other things. This is because, Stoffel showed that siRNA can be coupled efficiently to different fatty acids.
Participated in the study 38 children with moderate persistent to severe asthma, assigned randomly to either a training group or a control group exercise performance and physical strain induced bronchoconstriction 16 weeks was disassembled, rated, while daily doses of inhaled steroids and Pediatric asthma Quality of Life Questionnaire were also achieved record.
Three years ago the researchers headed by Kerry Sorghum, they report determined that to a class of anticonvulsant medication out of the nematode Caenorhabditis elegans live longer. But up to now they have do not really know what to be the drug, the worm indeed their longevity. They report on their latest findings the 24th October edition of the Public Library of Science Genetics. ‘We have learned that the medications neuronal at the worm head, at inhibit to sense of chemicals around them – the neurons are like the worm your nose,’says grain field Professor of developmental biology. ‘Like thread worms that are grown in a given foodstuff – scarce environment, the worm exposed the anticonvulsive ethosuximide live longer. Sequenced and worms ate plenty of food. This suggests that the worms’ feeling food control of controlling of its metabolism and life span. ‘.
In If thread worms sense that it groceries is abundant, your metabolism adapts accordingly. Their body respond to fast recording, to encourage fast growth and rapid aging, Kornfeld explains. In contrast, when the worms to feel lack of food, she make metabolic choices growth growth, delayed, power consumption and renew lifespan.