In the current study, Donato and colleagues have expanded, at work and examined the effects of overexpression and gene silencing LYN kinase in CML cell lines treated with imatinib. In addition, determined the level of LYN activation in samples from 12 imatinib-resistant patients, the BCR-ABL mutations and 6 patients whose tumor cells lacked sensitive to the drug but unable to tolerate unable to tolerate its side effects.
Imatinib is the standard therapy for newly diagnosed CML patients. However, it is in some patients resistance to the drug over time. In some patients, resistance develops in response to mutations in the BCR-ABL gene. In other cases, however, researchers found no mutations Previous work the resistance. Previous work suggested by Nicholas Donato, of the University of Michigan Comprehensive Cancer Center in Ann Arbor and other that one possible mechanism of this mutation – negative resistance of LYN kinase activation, which is usually controlled by BCR-ABL in CML cells.According to Channel NewsAsia several organizations Singapore – including AIDS Business Alliance is and respect and Action for AIDS – are working on the HIV / AIDS stigma the workplace and among the young to address. By courtesy of you may total Kaiser Daily Health Policy view Reports, search the archives , or sign up for mail notification in the Emperor Daily Health Policy Report Reprint for royal network a free service from The Henry Y. Publish. Kaiser Family Foundation. 2005 Advisory Board Company and Kaiser Family Foundation. All rights reserved.. Two thousand eight hundred and fifty-two in Singapore raising The number of new The number of new HIV / cases of AIDS Singapore is increasing, by 149 new circumstances reported to during the first six months of the year – Health Agency planning HIV / AIDS education efforts amplify a increased comparison to the number of new investigations over the same period last year, reported – Channel NewsAsia report.